Recent systematic reviews have shown cognitive benefits of computer-based cognitive training. Similarly, cognitive training (e.g., computer based cognitive process training) may improve cognition, mobility, and postural control in older adults. RT has been studied less extensively than aerobic training in older adults, particularly in Mild Cognitive Impairment (MCI). Both, AE and RT trials have reported positive results in improving cognitive performance, with consistent findings also observed after AE interventions lasting more than 3 months. Physical exercise, specifically aerobic exercise (AE) and progressive resistance training (RT), have been demonstrated to improve cognitive outcomes, along with improved physical capacity and mobility in older adults. Promising interventions for people with MCI include physical exercise, cognitive training, and vitamin D supplementation. Mild cognitive impairment (MCI) is thought to be an intermediate state between normal cognition of aging and very early dementia and, as a pre-dementia state, is commonly regarded as the optimal stage to intervene with preventive strategies and early treatments. Recently, there has been an important shift in interventional studies on dementia to targeting early stages or pre-dementia states. The cost associated with these dementia cases is over $800 billion US. Over 46 million people lived with dementia worldwide in 2015, with 1 new case every 4.1 s. These interventions may contribute to new approaches to stabilize and reverse cognitive-mobility decline in older individuals with MCI.
#Digit span cog lab demo trial#
The SYNERGIC Trial will establish the efficacy and feasibility of a multimodal intervention to improve cognitive performance and mobility outcomes in MCI. Secondary outcomes include neuroimaging, neuro-cognitive performance, gait and mobility performance, and serum biomarkers of inflammation (C reactive protein and interleukin 6), neuroplasticity (brain-derived neurotropic factor), endothelial markers (vascular endothelial growth factor 1), and vitamin D serum levels.
#Digit span cog lab demo plus#
The primary outcome measure is the ADAS-Cog (13 and plus modalities) measured at baseline and at 6 months of follow-up. placebo) in a quasi-factorial design, and one arm which receives all control interventions. sham) and vitamin D supplementation (3 × 10,000 IU/wk. Two-hundred participants with MCI aged 60 to 85 years old will be randomized to one of five arms, four of which include combined exercise plus combinations of dual-task cognitive training (real vs. The SYNERGIC trial (SYNchronizing Exercises, Remedies in GaIt and Cognition) is a multi-site, double-blinded, five-arm, controlled trial that assesses the potential synergic effect of combined AE and RT on cognition and mobility, with and without cognitive training and vitamin D supplementation in older adults with MCI. We also expect that adding cognitive training and vitamin D supplementation to the combined exercise, as a multimodal intervention, will have synergistic efficacy. We postulate that combined aerobic exercise (AE) and progressive resistance training (RT) (combined exercise) will have a better effect on cognition than a balance and toning control (BAT) intervention in older adults with MCI. Aerobic and progressive resistance exercises have benefits to cognitive performance, though evidence is somewhat inconsistent. Physical exercise, cognitive training, and vitamin D are low cost interventions that have the potential to enhance cognitive function and mobility in older adults, especially in pre-dementia states such as Mild Cognitive Impairment (MCI).
0 kommentar(er)
